How Psoriasis Medications Work

Psoriasis is a chronic autoimmune skin condition characterized by red, scaly patches and thickening of the skin. The goal of treatment is to reduce inflammation, slow down skin cell growth, and prevent new lesions from forming.

Topical Corticosteroids: The Gold Standard

The most effective treatment for mild to moderate psoriasis is topical corticosteroids. These medications work by:

• Reducing inflammation: Corticosteroids decrease the production of pro-inflammatory cytokines, which contribute to skin thickening and scaling.

• Slowing down skin cell growth: By inhibiting the proliferation of keratinocytes, corticosteroids help reduce the rate at which new skin cells are produced.

Alternative Treatments for Moderate to Severe Psoriasis

For patients with moderate to severe psoriasis, alternative treatments may be necessary. These include:

• Methotrexate: A systemic immunosuppressant that reduces inflammation and slows down skin cell growth.

• Cyclosporine: An immunosuppressant that inhibits T-cell activation, reducing inflammation and slowing down skin cell growth.

• Apremilast: A phosphodiesterase-4 inhibitor that reduces inflammation by decreasing the production of pro-inflammatory cytokines.